Conduct of five day high throughput transcriptomic dose response studies of selected chemicals for the NTP

Battelle Memorial Institute, Richland OH

Investigators

Abstract

These studies are being conducted to evaluate the hypothesis that benchmark dose/benchmark dose level (BMD/BMDL) analyses of transcriptional changes in the adult rat liver following short term oral exposure to a chemical will produce similar (if not slightly lower) points of departure compared to BMD/BMDL analyses of apical end-points and to evaluate reproducibility of the approach. This approach may be useful in comparing classes of compounds and providing quantitative data to inform risk assessments. Keywords: toxicity, high throughput transcriptomics, cancer genomics