Cross-CFDE semantic and spatial interoperability for anatomy

University Of Auckland, Auckland

Investigators

Abstract

The potential impact of the work to be done if it were successfully implemented. This proposal looks to establish three-way collaboration between SPARC, HuBMAP and Kids First (SHKF) as a means to develop coherent anatomical knowledge/data management strategies informed by clinical use-cases. SPARC seeks to apply, in the SHKF space, SPARC-related infrastructure (e.g. SciCrunch platform [1], ApiNATOMY connectivity [2] and flatmaps, 3D dynamic organ scaffolds [3]), procedures (e.g. curational pipeline) and expertise (e.g. clinical, knowledge- and bio-engineering, neuroscientific) to foster SHKF molecular/tissue/phenotype interoperability in support of discovery, modeling and hypothesis testing, initially in the areas of the neurology of the heart and colon. In the long-term (beyond the immediate scope of this project), this effort is expected to also set the stage, and eventually facilitate, modelling and simulation (M&S) efforts in the areas of physiology-based pharmacokinetics (PBPK) and paediatric allometry (PA).