Sex Differences in Methylome Alterations and Mutational Burden in Early Stage Melanoma
$95,969P01FY2020CANIH
University Of New Mexico Health Scis Ctr, Albuquerque NM
Investigators
Linked publications & trials
Paper 39123344Paper 38800658Paper 38232729Paper 37494457Paper 37494057Paper 37345045Paper 37015919Paper 37011054Paper 36926987Paper 36805567Paper 36652085Paper 36497341Paper 35876628Paper 35634240Paper 35343960Paper 35262173Paper 34981173Paper 34922919Paper 34898573Paper 34843679Paper 34607836Paper 34409386Paper 34031376Paper 33934340Paper 33768212Paper 33664338Paper 33661190Paper 33619278Paper 33545064Paper 33414132Paper 33272320Paper 32998984Paper 32856602Paper 32681635Paper 32643855Paper 32571778Paper 32064978Paper 31958143Paper 31935372Paper 31718536Paper 31663663Paper 31568773Paper 31520533Paper 31488411Paper 31435021Paper 30872112Paper 30803560Paper 30571972Paper 30529013Paper 30453881Paper 30211730Paper 30171176Paper 29975213Paper 29753029
Abstract
PROJECT SUMMARY/ABSTRACT The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. We will evaluate methylome alterations and mutational burden in the primary tumors of 1000 melanoma patients with the goal of 1) identifying underlying mechanisms for observed disparities in melanoma overall survival between men and women, and 2) identifying subclasses of methylome alterations and mutational signatures associated with sex and survival.
View original record on NIH RePORTER →