Mechanisms of Corneal Nerve Repair

$400,844R01FY2020EYNIH

University Of Illinois At Chicago, Chicago IL

Investigators

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Paper 35934279 Paper 35862373 Paper 35692510 Paper 35427568 Paper 35392370 Paper 35121423 Paper 34400306 Paper 34155284 Paper 34149247 Paper 32372335 Paper 32173376 Paper 31730836 Paper 31444394 Paper 30098191 Paper 29528507 Paper 29370308 Paper 29287709 Paper 28795242

Abstract

PROJECT SUMMARY The cornea is the most densely innervated tissue in humans. Peripheral corneal nerves regenerate follow injury. Our hypothesis is that VEGF is a critical determinant of corneal nerve regeneration after injury and that the signaling pathways which mediate neurogenesis are distinct from those which mediate angiogenesis. Aim 1 will characterize the mechanisms by which VEGF ligands mediate corneal nerve repair in vitro and in vivo. Aim 2 characterizes the ability of VEGF ligands to mediate repair in animal models of corneal injury.

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