The dynamics of chromatin topology in human cells

Division Of Basic Sciences - Nci

Investigators

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Abstract

I joined the NIH as a Stadtman Investigator in October, 2018. The major effort in FY2019 is to set up the new lab (including lab/office renovation and equipment/supplies purchasing), as well as to recruit multiple lab members (postdocs, postbacs). We are currently in the process of quantification and characterization of genome-wide DNA supercoiling levels in human cells. We are also further improving a previously developed single-cell whole-genome amplification method using the principle of linear amplification, which will benefit future single-cell studies in the lab.