Inhibitors of HBA1 and eNOS interaction

National Center For Advancing Translational Sciences

Investigators

Abstract

This project aims to identify small molecules that, like the mimetic peptide, dissociate HBA from eNOS to increase NO signaling across the MEJ. Such a molecule could accelerate the translation of this basic discovery into a drug that can increase myoendothelial NO signaling - providing an entirely novel approach to treating such diverse vascular diseases as hypertension, atherosclerosis, sickle cell anemia and malaria. During this period, the project team designed and optimized a high-throughput amenable assay to enable the envisioned screening.