Biologics Assay Development

National Center For Advancing Translational Sciences

Investigators

Abstract

This project seeks to expand NCGC's screening reach beyond traditional drugs into cutting edge biologics space, including antibodies, ADCs, proteins and other non-small molecule agents. Additionally, with over 200 approved recombinant protein products on the market and over 1,500 more in clinical trials, there exists a clinical need to identify effective combinations of small molecule and biotherapeutics. Thus, we aim to develop non-small molecule combinatorial high-throughput screening approaches to catalyze biologic and small molecule drug discovery. During this period, the team continued to assemble and curate more novel non-small molecule libraries. We have developed methodologies and equipment to handle aqueous based high-throughput screening methods allowing us access more non-small molecule screening modalities. In addition, we have also developed methodologies to explore combinatorial screening between antibodies and small molecules.