Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis

$75,235R37FY2019DENIH

University Of Pittsburgh At Pittsburgh, Pittsburgh PA

Investigators

Linked publications & trials

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Abstract

Abstract The goal of this diversity supplement (to parent grant R37 DE022550) is to support the efforts of an under-represented minority graduate student, Ms. Tiffany Taylor, in pursuing graduate work at the University of Pittsburgh on defining the molecular basis of immunity to oral Candida albicans infections. The parent grant focuses on innate immune mechanisms of oral mucosal immunity to candidiasis, and specifically how Type 17/IL-17-based immunity is activated in the oral mucosa. This supplement focuses on the role of an IL-17-induced RNA binding protein, Arid5a, in mediating IL-17-dependent antifungal signals, both in vivo and in vitro.

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