Brain Insulin Resistance and Development of Alzheimers Disease
$373,570R01FY2019AGNIH
Wake Forest University Health Sciences, Winston-Salem NC
Investigators
Linked publications & trials
Paper 39482741Paper 38946518Paper 38816203Paper 38746210Paper 38741246Paper 38204926Paper 38051041Paper 37732473Paper 37578773Paper 37452151Paper 36542537Paper 36065050Paper 35926332Paper 35920161Paper 35694859Paper 35421225Paper 34788804Paper 34753805Paper 34668083Paper 34637524Paper 34412057Paper 34258889Paper 33745805Paper 32739014Paper 30997482
Abstract
Project Summary R01 AG058571 Type 2 diabetes, characterized by insulin resistance in peripheral tissues such as skeletal muscle, increases AD risk. However, it is unclear whether there is a similar, or stronger, relationship between insulin resistance in the brain and AD. The goal of the proposed administrative supplement to Look AHEAD-MIND, while within the original scope, is to further unravel molecular pathways linking the intensive lifestyle intervention to the development of cognitive impairment by examining neural-derived blood exosome biomarkers for brain insulin resistance and Alzheimer's disease (AD) pathologies.
View original record on NIH RePORTER →