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Research Program: Cancer Basic Biology

$7,407P30FY2019CANIH

Fred Hutchinson Cancer Research Center, Seattle WA

Investigators

Jonathan A. Coopercontact

Linked publications, trials & patents

Trial NCT06995898Trial NCT06682039Trial NCT06484595Trial NCT06193070Trial NCT05947500Trial NCT05930496Trial NCT05183828Trial NCT04902144Trial NCT04751383Trial NCT04682301Trial NCT04667481Trial NCT04660331Trial NCT04539366Trial NCT04505553Trial NCT04502524Trial NCT04500548Trial NCT04496219Trial NCT04489719Trial NCT04472338Trial NCT04466475Trial NCT04447313Trial NCT04444232Trial NCT04442581Trial NCT04431479Trial NCT04410900Trial NCT04387227Trial NCT04384692Trial NCT04383743Trial NCT04375631Trial NCT04372927Trial NCT04370301Trial NCT04359784Trial NCT04336943Trial NCT04329065Trial NCT04282187Trial NCT04260776Trial NCT04257578Trial NCT04254133Trial NCT04231877Trial NCT04220229Trial NCT04211766Trial NCT04208724Trial NCT04205409Trial NCT04200482Trial NCT04198922Trial NCT04196010Trial NCT04195945Trial NCT04195633Trial NCT04194918Trial NCT04188912Trial NCT04175431Trial NCT04156828Trial NCT04155840Trial NCT04151940Trial NCT04120246Trial NCT04111497Trial NCT04083183Trial NCT04083170Trial NCT04081779Trial NCT04081298Trial NCT04062955Trial NCT04060849Trial NCT03999515Trial NCT03991884Trial NCT03986502Trial NCT03980769Trial NCT03970096Trial NCT03907527Trial NCT03891784Trial NCT03864419Trial NCT03807063Trial NCT03806192Trial NCT03781778Trial NCT03779867Trial NCT03779854Trial NCT03778021Trial NCT03776864Trial NCT03749460Trial NCT03747484Trial NCT03737955Trial NCT03723863Trial NCT03718338Trial NCT03672981Trial NCT03670966Trial NCT03670069Trial NCT03660930Trial NCT03649841Trial NCT03641287Trial NCT03606486Trial NCT03602898Trial NCT03600038Trial NCT03585231Trial NCT03574012Trial NCT03570476Trial NCT03531918Trial NCT03525106Trial NCT03523195Trial NCT03522584Trial NCT03518242Trial NCT03516812

Abstract

Cancer Basic Biology Program The Cancer Basic Biology Program (CBB) aims to understand the fundamental genomic and cellular mechanisms that regulate the normal and transformed phenotype; to develop new molecular approaches and tools to advance cancer diagnosis and therapy; and to develop with other Consortium programs the intellectual and technical infrastructure to advance translational cancer research. There are three major scientific themes: 1. The biology of the nucleus in normal and tumor cells, with a focus on mechanisms regulating altered gene expression and the loss of genome stability in cancer; 2. Regulation of normal and cancer cell phenotypes including the regulation of the cell cycle and motility, and the use of genetic, metabolic and high-throughput screening strategies to improve cancer diagnosis and therapy; and 3. Protein design and genome engineering as enabling technologies to advance basic and translational cancer biology. The CCSG supports this research program by providing key shared resources, particularly Genomics, Proteomics, Cellular Imaging and Comparative Medicine; administrative support for meetings, clubs and interest groups; and pilot funding and new investigator funds. The Cancer Basic Biology Program currently has 73 members from 18 departments and 2 Institutions. 42 members have primary appointments at FHCRC and 31 at UW. 68 Members (93%) have peer-reviewed funding or are newly recruited and supported by their institution. The Cancer Basic Biology Program currently has $32.6M in peer-reviewed funding (direct) $7.1 of which (21%) is from NCI. Due to the tradition of basic research in small independent laboratories, most support is in the form of R01s. The Cancer Basic Biology Program published a total of 1116 papers in the previous grant period: 12% were intra-programmatic, 17% were inter-programmatic, and 11% were inter-institutional.

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