PROJECT 1: GUANFACINE EFFECTS ON AUD AND NEURAL CORRELATES IN FEMALE AND MALE MICE
$225,361P01FY2019AANIH
Yale University, New Haven CT
Investigators
Linked publications, trials & patents
Paper 38184208Paper 37778006Paper 37396408Paper 36120181Paper 35978533Paper 35761351Paper 35727299Paper 35243706Paper 34965199Paper 34335180Paper 34311184Paper 33600842Paper 33450666Paper 33190310Paper 32805549Paper 32665024Paper 32527509Paper 32333417Paper 31821620Paper 31364813Paper 31347245Paper 31341936Paper 31058288Paper 30949562Trial NCT03764098Trial NCT00773357
Abstract
ABSTRACT: Alcohol use disorders (AUD) remain a significant problem for both women and men but stress and negative affect contribute to the initiation, maintenance of, and relapse to alcohol use in women, more so than for men. In Project 1, we will obtain preliminary data to 1) determine if guanfacine alters choice and stress-induced ethanol preference in male and female mice using a two-bottle choice drinking paradigm that is sensitive to stress, and 2) begin to determine the effects of ?2A adrenergic receptors and GABA neuron activity on ethanol-induced microglia alteration and synaptic density in female and male mice.
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