PROJECT 3: EVALUATION OF GUANFACINE ON DRINKING BEHAVIOR IN WOMEN AND MEN WITH ALCOHOL USE DISORDERS
$74,143P01FY2019AANIH
Yale University, New Haven CT
Investigators
Linked publications, trials & patents
Paper 38184208Paper 37778006Paper 37396408Paper 36120181Paper 35978533Paper 35761351Paper 35727299Paper 35243706Paper 34965199Paper 34335180Paper 34311184Paper 33600842Paper 33450666Paper 33190310Paper 32805549Paper 32665024Paper 32527509Paper 32333417Paper 31821620Paper 31364813Paper 31347245Paper 31341936Paper 31058288Paper 30949562Trial NCT03764098Trial NCT00773357
Abstract
ABSTRACT: Several lines of evidence indicate that drinking behavior in women is more likely to be motivated by affect regulation and stress, whereas drinking in men is motivated by stimulation and alcohol-related positive reinforcement. Project 3 will collect preliminary data for a Phase 2b double-blind, placebo-controlled, parallel-group study to examine sex differences in guanfacine's effect on 1) counteracting stress- and stimulation-based drinking behavior in the laboratory and 2) improving clinical outcomes during a subsequent treatment phase.
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