ANTECEDENTS TO LUNG INJURY IN THE PRETERM

$299,700R01FY2001HDNIH

Children'S Hospital Med Ctr (Cincinnati), Cincinnati OH

Investigators

Linked publications & trials

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Abstract

DESCRIPTION: (Adapted from the Investigator's Abstract): Preterm lambs will be delivered and various ventilatory maneuvers performed (varying oxygen, tidal volume, and PEEP) to determine which particular strategy causes the least amount of lung injury. Next, preterm lambs will receive exogenous surfactant with different concentrations and combinations of apoproteins to determine if the injury process can be modified. Then, lambs will be exposed to endotoxin in utero to examine the impact of "inflammatory priming" on the development of lung injury. Finally, the ventilation and surfactant strategies that are found to cause the least injury will be tested to see if the arrest in lung development can be prevented.

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