Core Services: Division of Microbiology, Pathogen Detection and Quantification Core

$228,044P51FY2019ODNIH

Tulane University Of Louisiana, New Orleans LA

Investigators

Linked publications, trials & patents

Paper 39453193 Paper 39436053 Paper 39398995 Paper 39289468 Paper 39164284 Paper 39149452 Paper 39133676 Paper 39131309 Paper 39066335 Paper 39066199 Paper 38942338 Paper 38675952 Paper 38638441 Paper 38617282 Paper 38577492 Paper 38543734 Paper 38528837 Paper 38461051 Paper 38368584 Paper 38135285 Paper 38092883 Paper 38075920 Paper 38039075 Paper 38037590 Paper 38014096 Paper 38014094 Paper 38005994 Paper 37965349 Paper 37961272 Paper 37961145 Paper 37934362 Paper 37925510 Paper 37896817 Paper 37886544 Paper 37871009 Paper 37796819 Paper 37771291 Paper 37766350 Paper 37766343 Paper 37737611 Paper 37734588 Paper 37712216 Paper 37693534 Paper 37689386 Paper 37668388 Paper 37662559 Paper 37658595 Paper 37658590 Paper 37629052 Paper 37628711 Paper 37563642 Paper 37513022 Paper 37497218 Paper 37480292 Paper 37479685 Paper 37457744 Paper 37417740 Paper 37399208 Paper 37398418 Paper 37366075 Paper 37293310 Paper 37279544 Paper 37244986 Paper 37162508 Paper 37153584 Paper 37090643 Paper 37080736 Paper 37073617 Paper 37036007 Paper 37022787 Paper 37012543 Paper 36992502 Paper 36992332 Paper 36992331 Paper 36975141 Paper 36870567 Paper 36865309 Paper 36845143 Paper 36753524 Paper 36753522 Paper 36732510 Paper 36726992 Paper 36726540 Paper 36721163 Paper 36717721 Paper 36680154 Paper 36678479 Paper 36670361 Paper 36650549 Paper 36560823 Paper 36526890 Paper 36526642 Paper 36517984 Paper 36502383 Paper 36377612 Paper 36290956 Paper 36275677 Paper 36210315 Paper 36181356 Paper 36174117

Abstract

Abstract ? Pathogen Detection and Quantification Core Maintenance of SPF status in macaque breeding colonies requires routine and accurate surveillance for the presence of infectious pathogens to maintain health of the animals and reduce risk of transmission. All viral screening assays for the TNPRC SPF breeding colony are currently being performed in the Pathogen Detection and Quantification Core (PDQC) at the TNPRC. Confirmatory testing for non-negative screening results is performed at the Pathogen Assay Laboratory (PAL) at the California National Primate Research Center (CNPRC), Charles River (CR), and National B Virus Resource Laboratory (NBVRL). This two-tiered testing algorithm (screening and confirmatory testing) between the PDQC and outside laboratories and experts has improved both accuracy and efficiency in the current diagnostics surveillance program for maintaining the SPF colonies over the previous 5-year period of this base grant. Transfer of the SPF surveillance program to the PDQC also has reduced; a) diagnostic testing costs, b) shipping of samples and, c) turn-around time for reporting test results. In addition, expanded diagnostics surveillance or screening to detect additional infectious agents (viral and non-viral) has been introduced based on emerging needs and adaptability to the PDQC testing platforms. It is recognized that accurate testing methods to especially avoid false negative results is essential. All breeding colony animals are tested at a minimum of twice a year during semi-annual health assessments in an effort to detect any outbreaks before they spread to large numbers of animals. Data are provided in the Research Strategy to support the need for continued surveillance at the proposed frequency and capacity. Additionally, leadership in the Division of Veterinary Medicine and PDQC personnel have contributed significantly to the recent publication produced by the Nonhuman Primate Research Consortium (NHPRC), and Breeding Colony Management Consortium (BCMC) on current pathogen testing methods and management in SPF macaque colonies.

View original record on NIH RePORTER →