The Role of Lymphoid Neogenesis in Lung Transplant Tolerance

$368,792P01FY2019AINIH

Washington University, Saint Louis MO

Investigators

Linked publications & trials

Paper 39605452 Paper 39422603 Paper 39167663 Paper 38522826 Paper 38488011 Paper 38403187 Paper 38329123 Paper 37818354 Paper 37619922 Paper 37566593 Paper 37487095 Paper 36853803 Paper 36719374 Paper 36603504 Paper 36450281 Paper 36189800 Paper 35967320 Paper 35880523 Paper 35749228 Paper 35691796 Paper 35689679 Paper 35603788 Paper 35510760 Paper 35285127 Paper 35238643 Paper 34966103 Paper 34913895 Paper 34446527 Paper 34320366 Paper 34155069 Paper 34147662 Paper 34020867 Paper 33782247 Paper 33655244 Paper 33651004 Paper 33621212 Paper 33444289 Paper 33196461 Paper 33044428 Paper 33039825 Paper 33008575 Paper 32976703 Paper 32969590 Paper 32786174 Paper 32750037 Paper 32444372 Paper 32183988 Paper 31721409 Paper 31647606 Paper 31452317 Paper 31278849 Paper 31167966 Paper 30992538 Paper 30990794 Paper 30830879 Paper 30772037 Paper 30758137 Paper 30661445 Paper 30582448 Paper 30582269 Paper 30561386 Paper 30381460 Paper 30378766 Paper 29781811 Paper 29683998 Paper 29567678 Paper 29263310 Paper 29212908 Paper 28945475 Paper 28929859 Paper 28818404 Paper 28730633 Paper 28090432 Paper 27861263 Paper 27650575 Paper 27536731 Paper 27344051 Paper 27273836 Paper 26614734 Paper 24034705

Abstract

PROJECT SUMMARY Lung transplantation remains the only available treatment for many patients, who suffer from pulmonary failure. However, outcomes after lung transplantation continue to lag behind those after transplantation of other organs. Current immunosuppressive strategies for lung transplant patients are based on protocols that have been successfully used for recipients of other organs. However, such approaches do not take into account that immune responses to lung grafts differ from other commonly transplanted organs. Utilizing new mouse models of lung transplantation we have uncovered that tolerance to pulmonary grafts is regulated locally through interactions of immune cells within lymphoid aggregates that are newly formed in the graft. This application proposes to study mechanisms how tolerance is regulated after pulmonary transplantation and will allow for the development of new therapeutic strategies for lung transplant patients.

View original record on NIH RePORTER →