STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS

$387,595R01FY2001EYNIH

University Of California San Francisco, San Francisco CA

Investigators

Linked publications & trials

Paper 32621915 Paper 30942636 Paper 30418333 Paper 30289792 Paper 29809266 Paper 29133438 Paper 28813578 Paper 28542028 Paper 28187079 Paper 28091782 Paper 28081943 Paper 27605534 Paper 27529328 Paper 27129902 Paper 26684783 Paper 26579566 Paper 26562632 Paper 26213154 Paper 26022084 Paper 25810480 Paper 25702187 Paper 25574902 Paper 25451018 Paper 25439610 Paper 25355212 Paper 25320059 Paper 25246513 Paper 24756510 Paper 24313606 Paper 24308559 Paper 23872368 Paper 23540524 Paper 23447587 Paper 22836262 Paper 22357849 Paper 22107118 Paper 22057193 Paper 21857186 Paper 21676928 Paper 20484638 Paper 19561602 Paper 19439598 Paper 19218231 Paper 18217815 Paper 17928552 Paper 17898211 Paper 17522180 Paper 17344406 Paper 17020634 Paper 17016529 Paper 16855115 Paper 16740582 Paper 16275836 Paper 16267215 Paper 16026853 Paper 15088719 Paper 12853416 Paper 12843271 Paper 12736348 Paper 12511086 Paper 12386328 Paper 11967892 Paper 11872845 Paper 11190031 Paper 11135259 Paper 11016571

Abstract

The primary goal of this project is to uncover physiological and anatomical correlates of amblyopia in both humans and monkeys. This will continue the P.I.'s previous grant concerning the structure of ocular dominance columns (ODC) in animals and humans. There are 5 new specific aims that he will investigate: (1) The effect of strabismus on periodicity of ocular dominance columns, (2) Possible disruption of intrinsic connections from layer 4C to layer 3 in V1, (3) Alterations in human amblyopes of the complete pattern of ODC's, the organization of CO stripes in V2, and the organization of other extrastriate visual areas, (4) the cortical locus of visual suppression in strabismus and (5) the identity of a visual area anterior to macaque dorsal V2 that contains a unique CO pattern. Together, these new experiments will extend the previous work by investigating mechanisms beyond the ODC's that might be responsible for the poor vision in amblyopia.

View original record on NIH RePORTER →