Cutaneous Adverse Drug Reactions

Division Of Basic Sciences - Nci

Investigators

Linked publications & trials

Abstract

We have continued to evaluate patients at risk for the development of cutaneous toxicities associated with molecularly targeted therapies. These evaluations include baseline evaluations prior to initiation of treatment and follow-up visits to monitor and treat these skin toxicities. We previously have worked and continue to work with oncology colleagues a) to optimally design treatment protocols to evaluate for and treat cutaneous toxicities, and b) to inform the research community of potentially newly described skin toxicities and methods for management of these adverse effects to optimize continued antineoplastic treatment of oncology patients through multiple peer-reviewed publications and lectures intramurally and extramurally. This fiscal year, we published a finding of hidradenitis suppurativa-like skin lesions with gamma-secretase inhibitors used to treat patients with desmoid tumors, providing insights into the pathogenesis of hidradenitis suppurativa.