Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicity

$376,464U01FY2018AGNIH

Kaiser Foundation Research Institute, Oakland CA

Investigators

Linked publications, trials & patents

Paper 39697086 Paper 39677464 Paper 39605349 Paper 39595838 Paper 39578048 Paper 39444005 Paper 39402379 Paper 39402332 Paper 39379761 Paper 39375347 Paper 39371140 Paper 39345521 Paper 39132494 Paper 38988034 Paper 38958117 Paper 38903124 Paper 38883718 Paper 38875039 Paper 38848188 Paper 38747395 Paper 38712163 Paper 38689945 Paper 38460116 Paper 38303547 Paper 38018496 Paper 38014121 Paper 37986756 Paper 37985223 Paper 37902753 Paper 37745545 Paper 37606973 Paper 37605362 Paper 37578203 Paper 37563872 Paper 37547016 Paper 37459083 Paper 37322115 Paper 37292975 Paper 37292694 Paper 37276135 Paper 37260021 Paper 37248328 Paper 37125552 Paper 37057157 Paper 36870337 Paper 36809476 Paper 36536382 Paper 36524738 Paper 36513155 Paper 36512954 Paper 36496055 Paper 36343257 Paper 36164936 Paper 36152763 Paper 35925737 Paper 35595958 Paper 35552371 Paper 35413975 Paper 35379992 Paper 35258170 Paper 35210353 Paper 35142023 Paper 35121993 Paper 35120553 Paper 34969069 Paper 34961556 Paper 34897654 Paper 34870676 Paper 34852950 Paper 34818016 Paper 34813858 Paper 34719765 Paper 34708190 Paper 34668191 Paper 34653962 Paper 34626181 Paper 34615521 Paper 34526147 Paper 34482642 Paper 34447927 Paper 34420950 Paper 34388701 Paper 34347531 Paper 34283993 Paper 34151428 Paper 34148364 Paper 34140411 Paper 34033622 Paper 34009663 Paper 33942053 Paper 33914085 Paper 33900044 Paper 33880508 Paper 33818911 Paper 33789584 Paper 33749651 Paper 33675056 Paper 33459717 Paper 33367843 Paper 33348181

Abstract

PROJECT SUMMARY The Adult Changes in Thought (ACT) study's second Specific Aim focuses on cognitive resilience; Aim 2c focuses on synaptic changes as a possible resilience mechanism. This Supplement evaluates related hypotheses regarding astrogliosis, inflammation, and synaptic toxicity by incorporating technological advances in Histelide (Histology and ELISA on a glass slide) that enable multiplexed assessment. The investigators will test the hypothesis that for a given level of amyloid beta (A?) and tau, astrogliosis (measured with GFAP), neuroinflammation (measured with Iba1), and synaptic degeneration (measured with synaptophysin) will be lower in people who are resilient to the neuropathological changes of Alzheimer's disease.

View original record on NIH RePORTER →