ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling

University Of California, San Francisco, San Francisco CA

Investigators

Linked publications & trials

Abstract

PROJECT? ?SUMMARY/ABSTRACT The? ?goal? ?of? ?this? ?project? ?is? ?to? ?enable? ?scientific? ?discovery? ?and? ?advances? ?in? ?biomedical? ?research? ?through the? ?development? ?of? ?cutting-edge? ?software? ?tools? ?that? ?provide? ?integrated? ?visualizations? ?and? ?analyses? ?of molecular? ?structures? ?and? ?related? ?biological? ?information.? ?? ?Our? ?tools? ?can? ?be? ?applied? ?to? ?diverse? ?types? ?of biomolecular? ?data,? ?including? ?atomic-resolution? ?coordinates,? ?3D? ?cryo-EM? ?density? ?maps,? ?and? ?protein and? ?nucleic? ?acid? ?sequences,? ?annotations,? ?and? ?networks.? ?We? ?focus? ?on? ?unmet? ?software? ?needs? ?for? ?basic and? ?applied? ?biomedical? ?research? ?using? ?highly? ?trained? ?and? ?talented? ?staff,? ?with? ?excellent? ?interdisciplinary knowledge? ?and? ?specialized,? ?state-of-the-art? ?expertise? ?in? ?software? ?engineering,? ?computer? ?graphics visualization,? ?and? ?data? ?analysis.? ?? ?Our? ?primary? ?efforts? ?are? ?in? ?the? ?interactive? ?visualization? ?and? ?analysis? ?of structures? ?of? ?molecules,? ?molecular? ?assemblies,? ?and? ?protein? ?sequence-structure? ?relationships.? ?? ?These areas? ?are? ?critical? ?for? ?addressing? ?important? ?and? ?highly? ?relevant? ?biomedical? ?problems? ?such? ?as identifying? ?the? ?molecular? ?bases? ?of? ?disease,? ?identifying? ?targets? ?for? ?drug? ?development,? ?designing? ?drugs, and? ?engineering? ?proteins? ?with? ?new? ?functions.? ?? ?Our? ?software? ?tools? ?enable? ?scientists? ?to? ?understand, analyze,? ?and? ?illustrate? ?to? ?others? ?the? ?important? ?principles? ?of? ?molecular? ?structure,? ?function,? ?and interactions.? ?These? ?tools? ?are? ?widely? ?recognized? ?as? ?works? ?of? ?the? ?highest? ?quality,? ?and? ?are? ?available? ?for free? ?on? ?our? ?website? ?in? ?binary? ?and? ?source-code? ?form.? ?? ?We? ?support? ?and? ?maintain? ?these? ?tools,? ?and provide? ?detailed? ?documentation? ?and? ?tutorials.? ?Our? ?technological? ?developments? ?are? ?disseminated widely? ?via? ?scientific? ?publications,? ?lectures,? ?software? ?distribution,? ?and? ?video? ?animations.