Glutamatergic and GABAergic projections from the ventral pallidum control motivated behaviors

Cold Spring Harbor Laboratory, Cold Spg Hbr NY

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Abstract

Project Summary Dysfunction in circuits mediating aversion and reward underlies mental disorders, such as anxiety, major depression and addiction. Whereas recent studies have identified the lateral habenula, raphe and ventral tegmental area as key regions mediating aversion and reward, little is known afferents influencing these structures. In this proposal, we will investigate the role of the ventral pallidum and its projections in aversion and reward encoding in mice. In Aim 1, we will characterize how glutamatergic and GABAergic neurons mediate aversion and reward in a place preference task. In Aim 2, we will characterize how glutamatergic and GABAergic projections to downstream targets mediate aversion and reward in a place preference task. In Aim 3, we will use single-unit recording techniques to characterize how glutamatergic and GABAergic neurons in the ventral pallidum encode aversion and reward in a cost-benefit decision making task. We will also test whether VP glutamatergic neurons are necessary for execution of behavioral choice. Understanding how ventral pallidal circuits mediates aversion and reward will help guide treatment for several mental disorders.