Project 2 - TB Translation as a Target

$447,069P01FY2018AINIH

Texas A&M Agrilife Research, College Station TX

Investigators

Linked publications & trials

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Abstract

Project Summary ? Project 2 ? Targeting Translation Translation plays a key role in the survival of any cell and is a hub for many regulatory pathways that control cellular growth. Due to this complexity, the ribosome has proven to be a vulnerable antibiotic target and several existing antituberculous compounds block translation. We have capitalized on recent advances in cryo-EM techniques to explore the unique structural aspects of the mycobacterial ribosome that might alter antimicrobial efficacy and be exploited by new therapeutics.

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