Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability

Jackson Laboratory, Bar Harbor ME

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Abstract

PROJECT SUMMARY Drug addiction is a critical public health issue with genetic and environmental causes. Worldwide, 246 million adults used an illicit drug in 2013, and > 10% of these users met DSM-IV criteria for substance abuse. Stress is a key environmental variable driving the development of addiction, and this effect is under strong genetic control. Despite tremendous