Investigating de novo gene evolution in Drosophila melanogaster
$399,820R01FY2018GMNIH
University Of California At Davis, Davis CA
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Paper 34791207Paper 33598134Paper 32962630Paper 32737121Paper 30484926Paper 30404774Paper 28968391Paper 26950216Paper 26809315Paper 26801179Paper 25950438Paper 25887180
Abstract
Most evolution is the result of modifications of biological function by natural selection. However, truly novel evolutionary innovations are also possible. One example is the recruitment of genes from ancestrally non-genic sequence, which has been described in several species using comparative genomics approaches. Here we focus on the early stages of de novo gene evolution by studying variation and function of such genes segregating in Drosophila melanogaster and fixed since the split with D. simulans.
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