Stable Water Isotope Labeling for Imaging of Rapidly Proliferating Cells

Division Of Basic Sciences - Nci

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Abstract

We are applying stable water isotope labeling followed by MRI for in vivo visualization of tumors in a pre-clinical model. We hope to implement such imaging in the clinical setting and directly compare its utility for cancer imaging to current standard cancer imaging, such as positron emission tomography. Our imaging approach is non-radioactive and the labeling with stable water isotopes has already been shown to be safe at the doses required for imaging. Furthermore, our methodology may be useful for visualizing immunotherapeutic products if they undergo ex vivo labeling during manufacture, for example during the cell culture processing.