Testing the Effects of Anthrax Immune Globulin (AIG) in a Canine Model of B. anthracis Toxin Associated Shock

Clinical Center

Investigators

Abstract

We previously developed an ICU supported canine model of B. anthracis toxin shock, which has provided essential insights into the pathogenic effects of LT and ET. Using this model we then demonstrated that during LT and ET challenges alone or together, while the benefit with standard hemodynamic was limited, Raxibacumab provided substantial benefit, reducing fluid and vasopressor needs and improving survival even if administered after the onset of hypotension. The goal of the present study is to determine whether AIG also augments standards hemodynamic support during LT and ET challenge together in this canine model. Studies have been completed examining the effects of AIG in this canine model and a manuscript has been submitted an is presently under its first revision for Intensive Care Medicine Experimental. Work from this study was presented at the 2015 International Conference of the American Thoracic Society.