VITRONECTIN--STRUCTURE/FUNCTION
$245,100R01FY2001CANIH
Albany Medical College, Albany NY
Investigators
Linked publications & trials
Paper 32667849Paper 28842322Paper 27524870Paper 27484721Paper 26066891Paper 26053065Paper 25051083Paper 24982443Paper 24634571Paper 23007402Paper 19379667Paper 19208746Paper 18957516Paper 18445685Paper 17631278Paper 17344041Paper 17257819Paper 16461772Paper 14681059Paper 14602715Paper 11051458
Abstract
DESCRIPTION: In Specific Aim 1, the PI proposes to test the role of vitronectin's RGD peptide and BD (basic domain) sequences in vitronectin function. In Specific Aim 2, she proposes to test the role of vitronectin's RG and BD sequence in the fibroblast-mediated endocytosis and degradation of vitronectin. In Specific Aim 3, she proposes to characterize ligand-binding properties of recombinant vitronectins that are mutated in RGD and/or BD.
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