INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES

$196,947R01FY2001AINIH

University Of California Los Angeles, Los Angeles CA

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Paper 19481124 Paper 17855515 Paper 16731908 Paper 16474136 Paper 15567494 Paper 15376630 Paper 15218172 Paper 15113907 Paper 14573816 Paper 12768027 Paper 12504548 Paper 12466482 Paper 12205777 Paper 11883197 Paper 11451488 Paper 11040121 Paper 10954572 Paper 10864667

Abstract

DESCRIPTION: For replication of influenza virus, 3 viral polymerase (3P) proteins (PA, PB1 and PB2) are necessary. The long term goal of this proposal is to find ways to interfere with the polymerase activity for a safe live virus vaccine. The aims of this proposal are: 1. how the polymerase complex is formed, 2. what are the functions of each polymerase protein, 3. what are the domains and sequence requirements for these functions, 4. what are the functions of nucleocapsid protein (NP) in modulating the polymerase activity, and 5. what are the requirements of type (A, B, and C) specificity for viral polymerases?

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