Internal Bonding in Proteins

$458,686R01FY2017GMNIH

Cornell University, Ithaca NY

Investigators

Linked publications & trials

Paper 38808365 Paper 37764437 Paper 36053833 Paper 35258946 Paper 34981860 Paper 33909430 Paper 33398661 Paper 33270217 Paper 32759212 Paper 32392067 Paper 32271570 Paper 31939671 Paper 31928007 Paper 31134683 Paper 30306573 Paper 29967418 Paper 29940109 Paper 29451381 Paper 29446945 Paper 29378960 Paper 28919647 Paper 28884632 Paper 28143938 Paper 28132613 Paper 28095675 Paper 28000446 Paper 27378298 Paper 27179474 Paper 26723596 Paper 26315852 Paper 26100791 Paper 26052263 Paper 25973573 Paper 25866611 Paper 25850343 Paper 25412765 Paper 25066622 Paper 25024008 Paper 24729761 Paper 24677212 Paper 24403017 Paper 24273465 Paper 24082119 Paper 23980156 Paper 23914144 Paper 23620713 Paper 23496746 Paper 23087598 Paper 22945426 Paper 22737044 Paper 22715321 Paper 22475198 Paper 22161955 Paper 22142378 Paper 21939202 Paper 21643583 Paper 21500792 Paper 21500791 Paper 21050858 Paper 20888834 Paper 20644980 Paper 20568747 Paper 20494507 Paper 20305729 Paper 20166738 Paper 20161452 Paper 20091207 Paper 20073062 Paper 20049918 Paper 20039620 Paper 20020472 Paper 20017135 Paper 20011673 Paper 19658975 Paper 19572703 Paper 19564690 Paper 19556395 Paper 19480420 Paper 19384995 Paper 19242966 Paper 19241469 Paper 19089955 Paper 18952103 Paper 18797518 Paper 18780343 Paper 18700740 Paper 18683966 Paper 18618612 Paper 18601387 Paper 18502794 Paper 18399682 Paper 18250334 Paper 18215513 Paper 18008324 Paper 17975838 Paper 17972284 Paper 17880128 Paper 17516673 Paper 17201452 Paper 17201450

Abstract

DESCRIPTION (provided by applicant): Our long-term objective is to ascertain how protein conformation plays a role in biological function and in various diseases. Our specific aims are to treat the role of basic physical forces, key interactions, key residues, as well as the role of conformation, with an improved coarse-grained UNRES model, in several biological systems related to specific diseases. We will also continue the development of our UNRES model of nucleic acids (NARES-2P) and merge UNRES and NARES-2P into a viable package, which will be provided to the community. We will demonstrate how these aims can lead to valid predictions of structures and folding pathways of proteins, and protein-nucleic acid and protein-protein complexes. Our main focus will involve the application of this methodology to specific biological problems.

View original record on NIH RePORTER →