Establishment and metabolic control of influenza-specific lung-resident memory B cells

University Of Alabama At Birmingham, Birmingham AL

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Abstract

? DESCRIPTION (provided by applicant): This project will confirm the early establishment of a protective lung resident memory B cell (BRM) population, and investigate the metabolic pathways that poise these cells to form antibody-secreting cells (ASCs). Various groups have studied the formation of Ag specific memory B cells, but it has not been in the context of a pathogen that holds significant.