VISUALIZ OF GASTROPOD MORPHOL: PHYLOGENY &HYDROSTATIC CHARACTERISTICS

$288,015P41FY2001RRNIH

Duke University, Durham NC

Investigators

Linked publications & trials

Paper 34391877 Paper 33070086 Paper 31713888 Paper 27018499 Paper 26837742 Paper 26071893 Paper 25952516 Paper 25936684 Paper 25262951 Paper 24683971 Paper 24423612 Paper 24386540 Paper 24269490 Paper 24076225 Paper 24027623 Paper 24027610 Paper 23957326 Paper 23615612 Paper 23553588 Paper 23357075 Paper 23349231 Paper 23227300 Paper 23204945 Paper 23116817 Paper 23065808 Paper 22996260 Paper 22825127 Paper 22618438 Paper 22485175 Paper 22363613 Paper 22351642 Paper 22241062 Paper 22156062 Paper 22142643 Paper 22117695 Paper 22056683 Paper 22049304 Paper 21991539 Paper 21988893 Paper 21912653 Paper 21867759 Paper 21846505 Paper 21820867 Paper 21752680 Paper 21749925 Paper 21743784 Paper 21683146 Paper 21677360 Paper 21625347 Paper 21572526 Paper 21558587 Paper 21445552 Paper 21419226 Paper 21413080 Paper 21320606 Paper 21243034 Paper 21233176 Paper 21163300 Paper 21145026 Paper 21134771 Paper 21119052 Paper 21075916 Paper 20928875 Paper 20890665 Paper 20879291 Paper 20842647 Paper 20808950 Paper 20740666 Paper 20600960 Paper 20595465 Paper 20572138 Paper 20564601 Paper 20420929 Paper 20399875 Paper 20373399 Paper 20187176 Paper 20175466 Paper 20146375 Paper 20142483 Paper 20096789 Paper 20059248 Paper 20035883 Paper 20034583 Paper 20011244 Paper 19994543 Paper 19960328 Paper 19902507 Paper 19860813 Paper 19703880 Paper 19702286 Paper 19629999 Paper 19589388 Paper 19587837 Paper 19545939 Paper 19542887 Paper 19490934 Paper 19349225 Paper 19333276 Paper 19302087 Paper 19236923

Abstract

Mice with segmental trisomy 16 (Ts65Dn mice) are at gene dosage imbalance for many of the same genes triplicated in human beings with Down Syndrome (DS), the leading genetic cause of mental retardation in human beings. Marked changes in brain volume and development are notable in DS. We have recently shown that Ts65Dn mice have a marked deficit in learning and memory tasks. We wish to compare the structure of affected mouse brains to controls, initially in adults and subsequently during development. Results will be compared to ongoing MRI studies of DS individuals at Johns Hopkins.

View original record on NIH RePORTER →