CHAR OF LOW BARRIER HYDROGEN BONDS IN SERINE PROTEASE &MODEL COMPOUNDS

$0P41FY2001RRNIH

University Of Wisconsin Madison, Madison WI

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Abstract

This investigation deals with the importance of low-barrier hydrogen bonds in the structure and function of enzymes. We need to synthesize a series of trifluormethyl ketone inhibitors and then characterize low-barrier hydrogen bonds between inhibitors and enzyme by NMR spectroscopic techniques. We also need to determine isotope effects and fractionation factors of these compounds.

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