LEUKOCYTE PHYSIOLOGY IN BLOOD IN SEPTIC NEONATES

$121,168P41FY2001RRNIH

University Of Calif-Los Alamos Nat Lab, Los Alamos NM

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Abstract

We have developed protocols to assess the physiology of isolated leukocytes and leukocytes in blood. These protocols involve the analysis of cell function and the expression of surface receptors indicative of cell activation. We are beginning to characterize the response of leukocytes in septic neonates to administration of G-CSF. A manuscript has been submitted and revisions are in process (Bellis, Sklar, Ohls, manuscript submitted).

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