XRAY DIFFRACTION OF CD45 CRYSTALS

$143,176P41FY2001RRNIH

Stanford University, Stanford CA

Investigators

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Abstract

CD45 is a transmembrane protein tyrosine phosphatase that possesses two phosphatase cores in the cytoplasmic portion and "receptor-like" domain in the extracellular portion. So far, there is no structural information on this family of protein tyrosine phosphatase. CD45 plays a key role in the signal transduction pathway mediated through T cell antigen receptor.

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