DIFFRACTION FROM CRYSTALS OF MULTIMODULE FIBRONECTIN CELL ADHESION FRAGMENTS

$143,176P41FY2001RRNIH

Stanford University, Stanford CA

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Abstract

Recognition of extracellular ligands by cell surface receptors (integrins) is critical for cell adhesion, migration and tracking and perhaps the metastatic spread of tumor cells. This recognition is mediated in part by an arginine-glycine-aspartic acid sequence in extracellular proteins. We have recently cloned and expressed larger multimodule fragments that each contain the module FN 11110. We have crystallized three of these fragments. These fragments are important structural candidates to reveal the 3D organization of the RGD site and synergistic sites in adjacent domains that are required for integrin recognition and adhesive function of the molecule. Synchrotron radiation is needed to collect heavy atom data from these small crystals.

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