EFFICIENT ONE POT SYNTHESIS OF JM3100 &ANALOGS: HIV PROTEASE INHIBITOR

$157,506P41FY2001RRNIH

Washington University, Saint Louis MO

Investigators

Linked publications & trials

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Abstract

An efficient one-pot synthetic route to JM3100 (AMD3100), a highly potent inhibitor of HIV multiplication entering clinical trials, is reported based on temporary protection of the cyclam followed by reaction with P,P'-dibromoxylene and deprotection to give the bis-cyclam. This route can readily be adapted to the production of analogs of JM3100.

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