IGF::OT::IGF TESTING OF COMBINATION IMMUNO AND CHEMOPREVENTION STRATEGIES FOR LYNCH SYNDROME GASTROINTESTINAL CANCER

Weill Medical Coll Of Cornell Univ, New York NY

Investigators

Abstract

Recent progress has been made in clinical immunotherapy of gastrointestinal cancers associated with Lynch Syndrome using frame-shift mutant peptide vaccines. Further development of such strategies requires preclinical models for testing of next generation vaccines and combination strategies with small-molecules that may synergize with or augment the vaccine effects.