Genetic Susceptibility And The Environment In Cancer Risk

$632,196ZIAFY2015ESNIH

National Institute Of Environmental Health Sciences

Investigators

Linked publications & trials

Paper 35554533 Paper 35466399 Paper 35042965 Paper 35031163 Paper 34983606 Paper 34847083 Paper 34411412 Paper 34341517 Paper 34292776 Paper 34234117 Paper 34146516 Paper 34127801 Paper 34101481 Paper 33990587 Paper 33769540 Paper 33597508 Paper 33495599 Paper 33473200 Paper 33471974 Paper 33398198 Paper 32930425 Paper 32424353 Paper 32409115 Paper 32359158 Paper 32115800 Paper 31951276 Paper 31911677 Paper 31605532 Paper 31387022 Paper 31147895 Paper 31015461 Paper 31001917 Paper 30989176 Paper 30988301 Paper 30938765 Paper 30879397 Paper 30879037 Paper 30832715 Paper 30821641 Paper 30794318 Paper 30683880 Paper 30649302 Paper 30608512 Paper 30601243 Paper 30554720 Paper 30380005 Paper 30277539 Paper 30243019 Paper 29996894 Paper 29915430 Paper 29545823 Paper 29373861 Paper 29059683 Paper 29058716 Paper 29025028 Paper 28836271 Paper 28830874 Paper 27864342 Paper 27788131 Paper 27773939 Paper 27697780 Paper 27386115 Paper 27383059 Paper 27378129 Paper 27153672 Paper 27040690 Paper 26883092 Paper 26732427 Paper 26673874 Paper 26393518 Paper 26384415 Paper 25953686 Paper 25751399 Paper 25715684 Paper 24651610 Paper 24501099 Paper 24130171 Paper 24037755 Paper 23705859 Paper 23636050 Paper 23578854 Paper 23473616 Paper 23129512 Paper 22792358 Paper 22549899 Paper 22479307 Paper 21643930 Paper 21456070 Paper 20972438 Paper 20810466 Paper 20719408 Paper 19706757 Paper 19417063 Paper 19273484 Paper 19048631 Paper 18708650 Paper 18449058 Paper 18203168 Paper 18166976 Paper 17568388

Abstract

Although the common polymorphisms associated with risk of developing prostate cancer have been investigated in a number of GWAS studies, the role of genetic variation in determining disease aggressiveness has not been well studied. We had previously identified polymorphisms near the KLK3 gene on chromosome 19q13 as being associated with disease aggressiveness and as part of a large meta-analysis of more than 25,000 cases, we have now extended that work showing that this polymorphism is associated with aggressive and high-grade prostate cancer. Few genetic risk factors have been uncovered that contribute specifically to the racial disparity in prostate cancer observed in African Americans. With the advent of Ancestry Informative Marker (AIM) single nucleotide polymorphism (SNP) panels and powerful genetic strategies such as Mapping by Admixture Linkage Disequilibrium (MALD) it is possible to discover genes that underlie ethnic variation in disease risk. Using these markers in the North Carolina-Louisiana Prostate Cancer Project we have identified areas on chromosome 8q24.21 and 11p13 associated with increased risk. Finally, we show that several common polymorphisms in one-carbon metabolism genes were associated with either DNA methylation at repetitive elements, or directly with breast cancer risk. DNA methylation can change in response to environmental exposures, such as chemical pollutants, diet, and other lifestyle factors. This study links changes in blood DNA methylation to future risk of developing cancer and may suggest lifestyle strategies for lowering risk.

View original record on NIH RePORTER →