Translational regulation of the breast cancer stem cell by eIF4G1

New York University School Of Medicine, New York NY

Investigators

Linked publications & trials

Abstract

? DESCRIPTION (provided by applicant): This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.