Viable but Nonculturable Mtb

$1,581,787U19FY2015AINIH

Weill Medical Coll Of Cornell Univ, New York NY

Investigators

Carl F Nathancontact Michael Stephen Glickman

Linked publications & trials

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Abstract

Tuberculosis (TB) takes longer to cure than almost any other bacterial infection. Subpopulations of Mycobacterium tuberculosis (Mtb) become phenotypically drug-tolerant in association with host-imposed stresses that put Mtb into a slowly-replicating or non-replicating state (here called NR for simplicity). We hypothesize that NR Mtb represent a major population of the

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