Kidney Segmentation and New Metrics to Predict Disease Progression in ADPKD

Mayo Clinic Rochester, Rochester MN

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Abstract

DESCRIPTION (provided by applicant): Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder affecting approximately 1 in 1000 Americans, and collectively represents a leading cause of renal failure. While over 90% of ADPKD cases can be diagnosed genetically through defects in ADPKD1 or ADPKD2 genes, the clinical course of an individual is highly variable. Investigations are ongoing to understand the biochemical basis for this variability, but other studies take a more pragmatic approach. They attempt to find biomarkers or features which can predict ADPKD progression. Perhaps the most notable recent such study is the Consortium for Radiologic Studies of Polycystic kidney disease (CRISP). CRISP was a longitudinal multi-institutional imaging study where the predictive value of several easily extracted image features were evaluated. The image features studied by CRISP are basic by design, permitting efficient extraction from large numbers of participants. Image features investigated by CRISP include total kidney volume (TKV), cyst volume, and % cyst volume. CRISP found TKV correlated with kidney function decline, measured by glomerular filtration rate (GFR) change over the course of a decade. Hundreds of standardized ADPKD imaging studies underwent TKV evaluations through the CRISP study, which includes Mayo Clinic. TKV is obtained via stereology, a technique which consists of a coarse grid overlaid on image slices; only points falling within a region of interest are labeled. Many stereology studies regard volume measurement as an end product and discard the raw grid, but in CRISP raw grids were preserved. Many more advanced features are possible, but due to high human interaction they were not previously considered feasible to obtain. We hypothesize raw stereology grids provide a rich source of a priori information, which can effectively constrain soft tissue segmentations of kidneys in MRI images, permitting efficient extraction of advanced analytic features that may better predict individual clinical prognosis and therapy requirements. This work will obtain segmentations of ADPKD kidneys using nothing but raw stereology grids, and optimize the results possible with this constraint. We are also evaluating the predictive value of a promising advanced feature called Cyst-Parenchyma Surface Area in a pilot study. Notably, these segmentations and advanced features will require no additional human interaction when applied to studies where stereology was routinely conducted, including the CRISP cohort.