NOVEL MECHANISMS REGULATING NITRIC OXIDE IN THE SKIN

$134,676P01FY2001ESNIH

Univ Of Med/Dent Nj-R W Johnson Med Sch, Piscataway NJ

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Abstract

Studies are proposed in this application to study N0S isoform expression in keratinocytes and the mechanisms by which G proteins control N0 production in the skin. The primary hypothesis to be tested is that G proteins participate in the regulation of N0 biosynthesis in keratinocytes following cytokine challenge or toxic injury.

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