Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells

National Institute Of Allergy And Infectious Diseases

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Abstract

A major focus of study during the past year has been to continue to better understand HIV-1 induced cell death at the molecular and cellular levels and to test therapeutic interventions in animal models. The lab continued their ongoing studies of different factors to better understand T cell death during HIV infection. The results of these studies are designed to help uncover and define the mechanisms involved in CD4 T cell depletion by specific viral gene products and in the context of viral infection.