Poxvirus Entry

$439,824ZIAFY2014AINIH

National Institute Of Allergy And Infectious Diseases

Investigators

Linked publications & trials

Paper 27423915 Paper 26136578 Paper 25728299 Paper 24920806 Paper 23816434 Paper 23395460 Paper 22999097 Paper 22754644 Paper 22194690 Paper 22114343 Paper 22013036 Paper 21347205 Paper 21295816 Paper 19812151 Paper 19805093 Paper 19428041 Paper 19217136 Paper 19036815 Paper 18596103 Paper 18417576 Paper 18353946 Paper 17553884 Paper 17409143 Paper 17192302 Paper 17146047 Paper 17005230 Paper 16973586 Paper 16940502 Paper 16364735 Paper 16352530 Paper 16339313 Paper 16144903 Paper 16103150 Paper 16014909 Paper 15956550 Paper 15890898 Paper 15795260 Paper 15767409 Paper 15761054 Paper 15567438 Paper 15367589 Paper 15194761 Paper 15163727 Paper 14963148 Paper 14963132 Paper 14963131 Paper 14671108 Paper 14671107 Paper 14581563 Paper 14557660 Paper 14532286 Paper 12885917 Paper 12706074 Paper 12634370 Paper 12610117 Paper 12552001 Paper 12388724 Paper 12350360 Paper 12097590 Paper 11983854 Paper 11752136 Paper 11689647 Paper 11602762 Paper 11462025 Paper 11390577 Paper 11312352 Paper 11289801 Paper 11289800 Paper 11145885 Paper 11119600 Paper 11112499 Paper 11035794 Paper 11000242 Paper 10982364 Paper 10906205 Paper 10906204 Paper 10756020 Paper 10729152 Paper 10666276

Abstract

The first step in virus replication is entry. The mechanisms used by poxviruses are complicated by the existence of two distinct infectious forms with different external membranes. Another complicating factor is the ability of vaccinia virus to enter cells through the plasma membrane and by endocytosis. We have identified a complex comprised of at least 11 proteins that are conserved in all poxviruses and required for entry of both infectious forms of virus. These proteins are conserved in all members of the poxvirus family, suggesting a common entry mechanism.

View original record on NIH RePORTER →