HHSN261201200020I/HHSN26100006 Title: Preclinical In Vitro And In Vivo Screening Assays For Cancer Preventative Reagent Development, Task Order Title: Evaluation on the Prevention by Actoplus/Met (Pi

University Of Alabama At Birmingham, Birmingham AL

Investigators

Abstract

This task order is to evaluate preclinical efficacy of ActoPlus/Met in preventing breast cancer in the methylnitrosourea (ER+) mammary cancer model (using a high-fat diet to mimic obesity/insulin resistance), and in the MMTV/Neu (ER-) mammary gland carcinogenesis model (using a high fat diet to mimic obesity).