The Manhattan HIV Brain Bank

$15,514U24FY2014MHNIH

Icahn School Of Medicine At Mount Sinai, New York NY

Investigators

Linked publications, trials & patents

Paper 39253970 Paper 38630782 Paper 38257772 Paper 37931057 Paper 37926797 Paper 37910505 Paper 37875652 Paper 37815677 Paper 37766236 Paper 37609328 Paper 37546734 Paper 37503603 Paper 37307400 Paper 37233903 Paper 37184401 Paper 37112989 Paper 36988209 Paper 36930640 Paper 36890725 Paper 36851531 Paper 36525955 Paper 36202168 Paper 36007132 Paper 35867351 Paper 35746739 Paper 35656871 Paper 35526056 Paper 35417540 Paper 35411474 Paper 35142024 Paper 35019681 Paper 34903055 Paper 34843091 Paper 34757975 Paper 34590409 Paper 34524914 Paper 34520593 Paper 34420144 Paper 34329400 Paper 34324449 Paper 34265825 Paper 34108514 Paper 34081663 Paper 33813555 Paper 33580123 Paper 33554087 Paper 33202420 Paper 33176710 Paper 33148994 Paper 33000167 Paper 32967753 Paper 32910432 Paper 32773479 Paper 32757979 Paper 32732283 Paper 32722761 Paper 32661005 Paper 32394397 Paper 32157292 Paper 31913991 Paper 31886690 Paper 31806564 Paper 31805958 Paper 31691183 Paper 31688040 Paper 31678140 Paper 31611355 Paper 31587032 Paper 31315440 Paper 31305330 Paper 31238091 Paper 31235531 Paper 31144289 Paper 31033097 Paper 30850623 Paper 30675981 Paper 30624650 Paper 30557159 Paper 30478799 Paper 30399527 Paper 30306495 Paper 30265439 Paper 30211610 Paper 30194646 Paper 30107467 Paper 30094630 Paper 30005012 Paper 29981000 Paper 29912063 Paper 29740045 Paper 29696578 Paper 29618649 Paper 29617912 Paper 29596112 Paper 29441001 Paper 29380545 Paper 29369399 Paper 29256040 Paper 28833868 Paper 28819214

Abstract

DESCRIPTION (provided by applicant): The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), has been a resource for the neuroAIDS research community since 1998. It performs neurologic, neuropsychological, psychiatric, general medical, and autopsy pathology assessments on a cohort of predominantly HIV-infected individuals, who agree to be organ donors upon demise, for the purposes of neuroAIDS and AIDS research. As a result of MHBB's observational longitudinal study, its tissue and fluids resources are densely annotated, and support a wide range of investigations into HIV-associated central (CNS) and peripheral nervous system (PNS) disorders. In the next cycle, MHBB will participate with other members of the NNTC to create a cohort optimized for the study of CNS reservoirs, aging, and pathogenesis of HIV-associated cognitive disorders persisting in the face of antiretroviral therapy. Specifically, MHBB will increase its representatin of older individuals, and those with stably suppressed plasma viral loads following variable CD4 nadirs. With this transition, MHBB will maintain important cohort characteristics reflective of the NYC epidemic, including prominent representation of minorities, women, and socio-culturally and medically complex individuals. MHBB will regularly upload clinical and pathologic information into a central consortium database, participate in all the protocol-defining and qualit assurance programs of the NNTC, and distribute its information, tissues, and fluids to investigators through central processes led by the NNTC data coordination center. MHBB will continue to analyze the behavioral and neurologic phenotypes of its cohort, to better understand how neuroAIDS disorders manifest in aging, demographically diverse individuals living through changes in therapeutic eras. Through observational studies, MHBB will better serve neuroAIDS researchers, as careful delineation of phenotype will assure better assignment of resources to research designs. Furthermore, observational study of HIV-associated CNS and PNS disease will allow MHBB to better understand neurobiologically relevant methods for subject characterization, and how to continue modifications of the cohort as the HIV epidemic continues to evolve.

View original record on NIH RePORTER →