Studies of Materials with Physiological Properties

$540,881R01FY2014GMNIH

Broad Institute, Inc., Cambridge MA

Investigators

Linked publications & trials

Paper 32920142 Paper 32231343 Paper 32150605 Paper 31184885 Paper 30762372 Paper 30133283 Paper 29954749 Paper 29651105 Paper 29584411 Paper 29073062 Paper 28869971 Paper 28809506 Paper 28678785 Paper 27978655 Paper 27799547 Paper 27518324 Paper 27398798 Paper 27064299 Paper 26933731 Paper 25660025 Paper 25569027 Paper 25546293 Paper 24290880 Paper 24273350 Paper 23980093 Paper 23807219 Paper 23725514 Paper 23477340 Paper 23245400 Paper 23074541 Paper 22853929 Paper 22536950 Paper 22434908 Paper 22323609 Paper 22242153 Paper 21696956 Paper 21585201 Paper 21334896 Paper 21183721 Paper 20696901 Paper 20616024 Paper 20140185 Paper 20081855 Paper 20080789 Paper 19819139 Paper 19151731 Paper 17786022 Paper 17486044 Paper 17462572 Paper 17406283 Paper 17348730 Paper 16720270 Paper 16630819 Paper 16415861 Paper 16099159 Paper 15680324 Paper 15345046 Paper 15146068 Paper 15123258 Paper 14700634 Paper 14536067 Paper 12770822 Paper 12526805 Paper 12060701 Paper 11948353 Paper 11930000 Paper 11784187 Paper 11602581 Paper 11483616 Paper 11416207 Paper 11137008 Paper 10869435 Paper 10825153 Paper 10702316

Abstract

DESCRIPTION (provided by applicant): The proposed research aims to address the gap between understanding and affecting disease by innovating in chemistry and exploring complex biology with small molecules. The research focuses on two pathways - electrophile stress-response pathways and chromatin-mediated gene regulatory pathways. These two pathways are fundamental to human disease biology, but remain poorly understood. The proposed research seeks to understand the selective interaction of subsets of electrophiles with the complex cell circuitry surrounding sulfur metabolites and how cellular electrophilic-stress response pathways might be modulated to develop new therapeutics. The proposed research also seeks to identify novel allosteric modulators of the polycomb repressive complex-2 (PRC2), the key mediator of epigenetic gene silencing, to illuminate novel cellular modes of regulation.

View original record on NIH RePORTER →