Histone Deacetylation in Oligodendrocyte Differentiation
$572,955R37FY2014NSNIH
Icahn School Of Medicine At Mount Sinai, New York NY
Investigators
Linked publications, trials & patents
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Abstract
DESCRIPTION (provided by applicant): This is the competitive renewal for a grant that has led to several key discoveries in the field of oligodendrocyte cell identity. Based on our previous record of productivity, solid preliminary data and resources and the collaboration with leaders in the field of epigenetics, chromatin and system biology, we propose to continue to elucidate mechanisms of oligodendrocyte differentiation and myelin formation. The proposed experimental plan will impact not only the field of neurobiology, but also address important biological questions with implications for a broad range of disciplines and contribute to the development of novel therapeutic strategies.
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