PROJECT F

$47,942P50FY2014GMNIH

Jackson Laboratory, Bar Harbor ME

Investigators

Linked publications & trials

Paper 35764696 Paper 34100066 Paper 33175657 Paper 31677600 Paper 30877080 Paper 29444201 Paper 29426289 Paper 29152612 Paper 29119144 Paper 28839117 Paper 28592500 Paper 28592499 Paper 27932493 Paper 27765810 Paper 27694113 Paper 27429446 Paper 27393554 Paper 27371833 Paper 27362481 Paper 27309819 Paper 27270587 Paper 27020856 Paper 26882987 Paper 26828925 Paper 26614740 Paper 26368021 Paper 26351520 Paper 26303911 Paper 26286858 Paper 26224782 Paper 26219736 Paper 26135136 Paper 26102561 Paper 25740934 Paper 25679959 Paper 25655028 Paper 25593000 Paper 25568937 Paper 25532804 Paper 25376053 Paper 25353171 Paper 25251056 Paper 25238945 Paper 25237114 Paper 25236450 Paper 25236449 Paper 25172922 Paper 25161222 Paper 25114278 Paper 24931995 Paper 24931977 Paper 24700285 Paper 24693920 Paper 24637805 Paper 24604780 Paper 24578350 Paper 24307629 Paper 24297548 Paper 24272351 Paper 24204223 Paper 24195963 Paper 24098153 Paper 24009241 Paper 23812996 Paper 23788651 Paper 23723228 Paper 23618393 Paper 23550134 Paper 23468881 Paper 23468633 Paper 23433259 Paper 23300418 Paper 23223940 Paper 23145029 Paper 23071457 Paper 23028291 Paper 22912808 Paper 22892839 Paper 22859403 Paper 22847377 Paper 22563380 Paper 22536897 Paper 22496633 Paper 22490822 Paper 22448268 Paper 22384400 Paper 22384396 Paper 22384395 Paper 22384394 Paper 22345612 Paper 22345611 Paper 22345610 Paper 22260749 Paper 22174259 Paper 21765459 Paper 21734011 Paper 21623374 Paper 21493779 Paper 21450099 Paper 21427413

Abstract

Project F: Genetics of mRNA processing; Joel H. Graber (Jackson) A complete model of gene regulation requires understanding control at all stages of expression from DNA through mRNA to final protein product. Response to environmental changes, such as diet, involves changes in expression at multiple stages of activation. Genetic bases for differences in post-transcriptional processing, such as alternative splicing and alternative polyadenylation, remain poorly understood. Genetically defined strains of mice, such as the DO and RIX, provide a powerful means of investigating genetic differences in gene expression and regulation in response to controlled changes in environment. Working in collaboration with projects C, D, and E we will investigate genetic differences in mRNA processing in response to dietary variation between normal chow, high vitamin D content, and high fat content.

View original record on NIH RePORTER →