Investigating the hair-bundle state space in an exploration of inner ear tuning

Weill Medical Coll Of Cornell Univ, New York NY

Investigators

Linked publications & trials

Abstract

DESCRIPTION (provided by applicant): Noise-induced, drug-induced, and congenital hearing loss results from damage to hair cells, the sensory receptors of the inner ear. With half of Americans over 75 afflicted by moderate to severe hearing impairment and a worldwide rise in the prevalence of hearing impairment in younger adults, hearing loss is a significant public-health concern. Knowledge of the normal operation of the hair cell-including that of its mechanical antenna, the hair bundle-will contribute to understanding the pathophysiology of hearing loss and developing treatments for it. The proposed study seeks to examine the dynamical properties of a hair bundle that underlie its ability to amplify mechanical stimuli. As a dynamical system, the activity of a hair bundle can be characterized by a state space that describes the bundle's behavior under various conditions. Included in the state space is a Hopf bifurcation, an instability that endows the hair bundle with the ability to self-tune near criticalty. This dynamical system can be readily explored by manipulation of two control parameters, offset force and stiffness. I will attempt to coerce the hair bundle to cross its critical point, demonstrating for the first time the presence of a Hopf bifurcation embedded in hair-bundle mechanics. This demonstration will provide a tool for further investigation of phenomena characteristic of the active process in hearing. Thus, by controlling mechanical properties, I shal elucidate the functions of hair bundles that endow humans with highly resolved auditory sensation.