Pharmacology of Lifespan Extension
$582,004R01FY2014AGNIH
Buck Institute For Research On Aging, Novato CA
Investigators
Linked publications & trials
Paper 34467850Paper 32550490Paper 31820364Paper 30973028Paper 30688027Paper 30194090Paper 29630057Paper 28836615Paper 28473732Paper 28220799Paper 27783938Paper 27773573Paper 27220516Paper 27078872Paper 26643314Paper 26377470Paper 25554795Paper 24123581Paper 23793570Paper 23303664Paper 23097491Paper 22771382Paper 22573480Paper 22534883Paper 22226190Paper 21562563Paper 21451522Paper 20816092Paper 18755260Paper 16099946
Abstract
7. ABSTRACT We have discovered a series of chemical compounds that delay the onset of age-related pathology and extend lifespan. These compounds were identified in focused chemical screens and high throughput screens of both synthetic compounds and natural products. Here we propose to identify the mechanism of lifespan extension with a focus on vitamin D which we have shown maintains protein homeostasis and extends lifespan in C. elegans. This will uncover novel mechanisms for interventions in aging and age-related disease.
View original record on NIH RePORTER →